Description

4,4,4-Trifluoro-1-Phenylbutane-1,3-Diol is a high-value fluorinated organic building block characterized by a phenyl-substituted diol structure with a terminal trifluoromethyl group. This compound matters for its unique combination of aromaticity, polarity, and the stability imparted by fluorine atoms, making it a versatile intermediate in advanced synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring enhanced metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can improve bioavailability and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Advanced Polymer Modifiers: Incorporated into specialty polymers to introduce fluorine for altered surface properties, chemical resistance, or optical characteristics.
• Asymmetric Catalysis & Ligand Development: Utilized as a chiral pool starting material or to construct sophisticated ligands for metal-catalyzed reactions.
• Academic & Industrial R&D: A valuable compound for methodological studies in organic synthesis, particularly in fluorination chemistry and diol functionalization.

Basic Information

Item	Detail
Product Name	4,4,4-Trifluoro-1-Phenylbutane-1,3-Diol
CAS No.	108535-37-1
Molecular Formula	C10H11F3O2
Molecular Weight	220.19 g/mol
Synonyms	1-Phenyl-4,4,4-trifluorobutane-1,3-diol; 4,4,4-Trifluoro-1-phenyl-1,3-butanediol; α-Phenyl-β-hydroxy-γ,γ,γ-trifluorobutanol; 1,3-Butanediol, 4,4,4-trifluoro-1-phenyl-; 108535-37-1; 4,4,4-Trifluoro-1-phenylbutane-1,3-diol; TFBD
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluoro-1-Phenylbutane-1,3-Diol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy. Certificates of Analysis (COA) documenting all critical parameters are available upon request to ensure full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect product quality and stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.