Description

tert-Butyl n-[3-(Aminomethyl)Benzyl]Carbamate is a protected amine derivative, specifically a carbamate, that serves as a versatile and critical building block in advanced organic synthesis. Its primary value lies in providing a masked primary amine functionality, which is essential for the controlled, sequential construction of complex molecules, particularly in pharmaceutical research. This intermediate is highly sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammation.
• Peptidomimetic Synthesis: Used to introduce benzylamine-derived side chains or as a protected amino component in the construction of peptide-like molecules.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides that require specific amine-containing scaffolds.
• Ligand and Catalyst Development: Employed in the creation of novel chelating ligands or organocatalysts for asymmetric synthesis.
• Polymer Modification: Can be used to functionalize polymers by introducing reactive amine sites after deprotection.
• Chemical Biology Probes: Useful for labeling or modifying biomolecules in research applications where a protected amine handle is required.

Basic Information

Product Name	tert-Butyl n-[3-(Aminomethyl)Benzyl]Carbamate
CAS No.	108467-99-8
Molecular Formula	C14H22N2O2
Molecular Weight	250.34 g/mol
Synonyms	3-[[(tert-Butoxycarbonyl)amino]methyl]benzylamine; 1,3-Benzenedimethanamine, N1-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyl (3-(aminomethyl)benzyl)carbamate; Boc-3-(aminomethyl)benzylamine; N-Boc-1,3-phenylenedimethanamine; N-(tert-Butoxycarbonyl)-3-(aminomethyl)benzylamine; 3-(Aminomethyl)benzyl carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[3-(Aminomethyl)Benzyl]Carbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.