Description

Substance P, Arg(1)-Cl2-Phe(5)-Asn(6)-Trp(7,9)-Nle(11)- CAS NO 108376-57-4 is a synthetic, modified analog of the neuropeptide Substance P, designed for enhanced stability and receptor binding specificity. This compound is critical for advanced research in neurobiology, pain signaling, and inflammatory pathways, offering a valuable tool for studying tachykinin receptor interactions. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for neurological and inflammatory disorders.

Application

• Neuroscience Research: A key tool for investigating the role of Substance P and neurokinin-1 (NK1) receptors in pain transmission, neurogenic inflammation, and central nervous system signaling.
• Drug Discovery & Development: Used as a reference standard or active pharmacological agent in high-throughput screening (HTS) assays to identify and validate new NK1 receptor antagonists.
• In Vitro & In Vivo Studies: Employed in cell-based assays and animal models to study tachykinin-mediated processes, including emesis, depression, and migraine pathophysiology.
• Biochemical Characterization: Serves as a ligand in receptor binding studies, affinity measurements, and structure-activity relationship (SAR) analysis for peptide analogs.
• Academic & Clinical Research: Supports fundamental research into the mechanisms of chronic pain, asthma, inflammatory bowel disease, and other conditions linked to Substance P pathways.

Basic Information

Product Name	Substance P, Arg(1)-Cl2-Phe(5)-Asn(6)-Trp(7,9)-Nle(11)- CAS NO 108376-57-4
CAS No.	108376-57-4
Molecular Formula	C70H98Cl2N20O13S
Molecular Weight	~1546.6 g/mol
Synonyms	[Arg1, D-Cl2-Phe5, Asn6, Trp7,9, Nle11]-Substance P; Modified Substance P analog; Substance P (1-11), [Arg1, 3,5-Dichloro-D-Phe5, Asn6, Trp7,9, Nle11]-; Tachykinin receptor ligand; NK1 receptor ligand; Neurokinin-1 agonist/antagonist research compound; SP analog
EINECS	Contact for details

Quality Control

Our Substance P analog is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.