Description

Trizma Citrate Monobasic is a high-purity organic salt derived from the combination of tris(hydroxymethyl)aminomethane (Tris) and citric acid. This compound serves as a critical buffering agent, offering superior pH stability and biocompatibility in complex biochemical systems. It is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and biotechnology sectors who require precise and reliable buffer components for sensitive applications.

Application

• Biochemical & Diagnostic Reagent Buffer: A key component in buffer systems for enzyme assays, immunoassays, and diagnostic kit formulations.
• Pharmaceutical Excipient: Used as a buffering agent in parenteral formulations, ophthalmic solutions, and topical preparations to maintain physiological pH.
• Cell Culture & Molecular Biology: Provides a stable pH environment for cell growth media, protein purification, electrophoresis, and PCR master mixes.
• Chromatography: Employed in the mobile phase for ion-exchange and affinity chromatography to separate biomolecules.
• Cosmetic Formulations: Acts as a pH adjuster and stabilizer in skin care products and lotions.
• Food Additive (where compliant): Can function as an acidity regulator and preservative in certain food processing applications.

Basic Information

Product Name	Trizma Citrate Monobasic
CAS No.	108321-33-1
Molecular Formula	C9H17NO8
Molecular Weight	267.24 g/mol
Synonyms	Tris Citrate Monobasic; Tris(hydroxymethyl)aminomethane Citrate Monobasic; Trometamol Citrate; 2-Amino-2-(hydroxymethyl)-1,3-propanediol Citrate (1:1); TRIS Citrate; Citric Acid Tris Salt; Tromethamine Citrate; Aminotris(hydroxymethyl)methane Citrate
EINECS	Contact for details

Quality Control

Our Trizma Citrate Monobasic is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets stringent specifications for purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identification, and impurity profiles. The product is suitable for applications requiring high-grade materials, including those following GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0 %
pH (1% Solution)	3.5 - 4.5
Loss on Drying	≤ 1.0 %
Heavy Metals (as Pb)	≤ 10 ppm
Residue on Ignition	≤ 0.1 %
Endotoxin (where applicable)	< 0.25 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.