Description

H-Pro-Pna Tfa is a protected amino acid derivative, specifically an N-terminal Boc-protected proline amide with a trifluoroacetyl (Tfa) protecting group on the aniline nitrogen. This compound is a crucial high-purity building block in the synthesis of complex peptides and peptidomimetics, offering orthogonal protection strategies for advanced solid-phase and solution-phase chemistry. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutic agents, diagnostic probes, and bioactive compounds.

Application

• Peptide Synthesis: As a key intermediate for introducing proline residues with orthogonal side-chain protection in complex peptide sequences.
• Pharmaceutical Research: Building block for the development of peptidomimetic drug candidates targeting various diseases.
• Combinatorial Chemistry: Used in the generation of diverse chemical libraries for high-throughput screening in drug discovery.
• Bioconjugation: Intermediate for creating labeled peptides or peptide-protein conjugates used in diagnostics and biochemical assays.
• Agrochemical Research: Potential intermediate in the synthesis of bioactive peptide-like compounds for crop protection.
• Academic Research: Tool compound for studying peptide structure-activity relationships and developing new synthetic methodologies.

Basic Information

Product Name	H-Pro-Pna Tfa
CAS No.	108321-19-3
Molecular Formula	C₁₈H₂₁F₃N₂O₅
Molecular Weight	402.37 g/mol
Synonyms	Boc-Pro-PNA(Tfa)-OH; Boc-L-Prolyl-N-(2,2,2-trifluoroacetyl)-1,4-phenylenediamine; N2-[(1,1-Dimethylethoxy)carbonyl]-N1-(2,2,2-trifluoroacetyl)-1,4-benzenediamine-L-prolineamide; Nα-Boc-Nδ-Tfa-1,4-diaminobenzoyl-L-proline; Boc-Pro-Pna(Tfa); H-Pro-PNA(Tfa)-OH, Boc protected; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-N-(4-((2,2,2-trifluoroacetyl)amino)benzoyl)pyrrolidine-1-carboxamide
EINECS	Contact for details

Quality Control

Our H-Pro-Pna Tfa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing the specific results for your batch. Our quality standards are designed to meet the rigorous demands of GMP-grade pharmaceutical synthesis and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-50° to -56° (c=1, in DMF)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.