Description

Cyclohexanecarbonitrile, 1-Hydroxy-2-(1-Methylethyl)-, (1R,2S)-Rel- (9Ci) is a chiral, hydroxylated cyclohexanecarbonitrile derivative, a high-value intermediate prized for its defined stereochemistry. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, enabling precise control over the final product's three-dimensional structure. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers developing advanced active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where stereochemical purity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective pesticides and herbicides where specific isomer activity is required for efficacy and environmental safety.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands and catalysts used in enantioselective chemical transformations.
• Fine Chemical & Specialty Material Production: Employed in the manufacture of high-performance polymers, liquid crystals, and other advanced materials requiring specific molecular geometry.
• Academic & Industrial Research: A valuable compound for methodological studies in organic synthesis, stereochemistry, and process chemistry within R&D laboratories.

Basic Information

Product Name	Cyclohexanecarbonitrile, 1-Hydroxy-2-(1-Methylethyl)-, (1R,2S)-Rel- (9Ci)
CAS No.	108168-70-3
Molecular Formula	C10H17NO
Molecular Weight	167.25 g/mol
Synonyms	(1R,2S)-rel-1-Hydroxy-2-isopropylcyclohexanecarbonitrile; 1-Hydroxy-2-(1-methylethyl)cyclohexanecarbonitrile, (1R,2S)-rel-; (1R,2S)-rel-2-Isopropyl-1-hydroxycyclohexanecarbonitrile; rel-(1R,2S)-1-Hydroxy-2-isopropylcyclohexanecarbonitrile; Cyclohexanecarbonitrile, 1-hydroxy-2-(1-methylethyl)-, (1R,2S)-rel-; 108168-70-3; (1R,2S)-1-Hydroxy-2-isopropylcyclohexanecarbonitrile (relative configuration)
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonitrile, 1-Hydroxy-2-(1-Methylethyl)-, (1R,2S)-Rel- (9Ci) is produced under strict quality management systems to ensure batch-to-batch consistency and high stereochemical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, to verify identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.