Description

Neuropeptide Y, Nle(4)- is a synthetic analog of the endogenous Neuropeptide Y (NPY), a potent neuromodulator involved in numerous physiological processes. This modified peptide, where a norleucine residue replaces the native amino acid at position 4, offers enhanced stability for research applications, making it a critical tool for studying NPY receptor interactions and signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on neuroscience, metabolic disorders, and cardiovascular research.

Application

• Neuroscience Research: A key reagent for investigating the role of NPY in appetite regulation, anxiety, stress response, and circadian rhythms.
• Receptor Binding Studies: Used in competitive binding assays (e.g., with Y1, Y2, Y4, Y5, and y6 receptors) to characterize receptor affinity and selectivity.
• Pharmacological Profiling: Essential for the in vitro and ex vivo screening and development of novel NPY receptor agonists or antagonists.
• Metabolic Disorder Studies: Applied in research models exploring NPY's influence on energy homeostasis, obesity, and diabetes.
• Cardiovascular Research: Utilized to study NPY's effects on vascular tone, blood pressure, and heart function.
• Biochemical Standard: Serves as a reference standard in analytical methods such as HPLC and mass spectrometry for peptide quantification and purity assessment.

Basic Information

Product Name	Neuropeptide Y, Nle(4)-
CAS No.	107949-91-7
Molecular Formula	C190H287N55O57S2
Molecular Weight	4253.7 g/mol
Synonyms	NPY (4-Norleucine); [Nle4]-Neuropeptide Y; Neuropeptide Y (4-Nle); Human, Porcine Neuropeptide Y (Nle4); H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2 (Nle4); [4-Nle]-NPY
EINECS	Contact for details

Quality Control

Our Neuropeptide Y, Nle(4)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) documenting all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (K.F.)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.