Description

Cyclopropanecarboxamide, 2-(1,1-Dimethylethyl)-, (1R-Trans)- (9Ci) is a high-purity, stereochemically defined cyclopropane derivative, a crucial building block in advanced organic synthesis. Its value lies in the unique structural and stereochemical properties imparted by the trans-configured cyclopropane ring with a tert-butyl substituent, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, where such chiral intermediates are key to creating compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates requiring rigid, three-dimensional structural motifs.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced crop protection agents, where the cyclopropane ring can enhance stability and bioactivity.
• Ligand and Catalyst Development: Used in the design and synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specialized thermal or mechanical properties due to the strained ring system.
• Chemical Biology Probes: Employed in the synthesis of molecular probes to study enzyme mechanisms or biological pathways, leveraging its defined stereochemistry.

Basic Information

Product Name	Cyclopropanecarboxamide, 2-(1,1-Dimethylethyl)-, (1R-Trans)- (9Ci)
CAS No.	107912-94-7
Molecular Formula	C8H15NO
Molecular Weight	141.21 g/mol
Synonyms	(1R,2R)-2-(tert-Butyl)cyclopropanecarboxamide; (1R-trans)-2-tert-Butylcyclopropanecarboxamide; trans-2-tert-Butylcyclopropanecarboxamide; (1R,2R)-2-tert-Butylcyclopropanecarboxylic acid amide; 2-(1,1-Dimethylethyl)cyclopropanecarboxamide, (1R,2R)-; (1R,2R)-2-(tert-Butyl)cyclopropanecarboxylic acid amide
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxamide, 2-(1,1-Dimethylethyl)-, (1R-Trans)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity verification, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.