Description

2-Amino-4,4-Difluorobutanoic Acid is a high-purity, non-natural fluorinated amino acid building block essential for advanced organic synthesis. This compound is valued for its ability to introduce fluorine atoms and a carboxylic acid handle into complex molecular architectures, significantly altering physicochemical properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated peptides, protease inhibitors, and novel drug candidates where fluorine substitution enhances metabolic stability and bioavailability.
• Agrochemical Research: Used in the synthesis of advanced herbicides, pesticides, and plant growth regulators that benefit from the unique properties of fluorine.
• Peptidomimetics & Bio-conjugation: Serves as a constrained, fluorinated building block in the design of peptide analogs and for creating stable bioconjugates and linkers.
• Material Science: Employed in the synthesis of specialized polymers, coatings, and liquid crystals where fluorinated amino acids can impart specific surface properties and stability.
• Chemical Biology Probes: Integral for creating fluorinated analogs of natural amino acids to study protein structure, function, and interactions via 19F NMR spectroscopy.
• Catalyst & Ligand Development: Used to construct novel chiral ligands and organocatalysts containing fluorine motifs for asymmetric synthesis.

Basic Information

Product Name	2-Amino-4,4-Difluorobutanoic Acid
CAS No.	107910-31-6
Molecular Formula	C4H7F2NO2
Molecular Weight	139.10 g/mol
Synonyms	4,4-Difluoro-DL-norvaline; 2-Amino-4,4-difluorobutanoic acid; DL-4,4-Difluoronorvaline; 4,4-Difluoronorvaline; (±)-2-Amino-4,4-difluorobutanoic acid; 4,4-Difluoro-2-aminopentanedioic acid (deprecated); Norvaline, 4,4-difluoro-
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-4,4-Difluorobutanoic Acid is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay, chiral purity (where applicable), and impurity profiles. Our quality commitment supports applications requiring high standards, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.