Description

2,2-Difluorocyclopropane-1-Carboxamide is a specialized fluorinated cyclopropane derivative, a high-value building block prized for its unique three-membered ring structure and fluorine atoms. This compound matters as a critical intermediate in modern synthetic organic chemistry, enabling the introduction of structural complexity and desirable physicochemical properties into target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by advanced material scientists exploring new functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, antiviral agents, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the difluorocyclopropane moiety can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing novel fluorinated polymers or liquid crystals with specific optical or electronic properties.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or molecular probes for studying biological mechanisms and interactions.
• Catalyst & Ligand Development: Acts as a scaffold for creating novel chiral ligands or organocatalysts used in asymmetric synthesis.
• Academic & Contract Research: Essential for methodological development and exploratory synthesis in university and CRO laboratory settings.

Basic Information

Product Name	2,2-Difluorocyclopropane-1-Carboxamide
CAS No.	107872-84-4
Molecular Formula	C4H5F2NO
Molecular Weight	121.09 g/mol
Synonyms	2,2-Difluorocyclopropanecarboxamide; 2,2-Difluorocyclopropane Carboxylic Acid Amide; 1-Carbamoyl-2,2-difluorocyclopropane; Difluorocyclopropanecarboxamide; 2,2-Difluoro-1-cyclopropanecarboxamide; 2,2-Difluorocyclopropane-1-carboxylic acid amide; 107872-84-4 (CAS)
EINECS	Contact for details

Quality Control

Our 2,2-Difluorocyclopropane-1-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable performance in your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. The material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.