Description

N(Alpha)-Acetylhirudin(45-65) CAS NO 107569-56-2 is a specific, chemically modified fragment of the potent natural thrombin inhibitor hirudin. This acetylated peptide sequence is critical for advanced biochemical research and development, particularly in the study of blood coagulation mechanisms and serine protease inhibition. It serves as a valuable reference standard and intermediate for pharmaceutical R&D teams, diagnostic manufacturers, and academic institutions focused on hematology and cardiovascular disease.

Application

• Biochemical Research: Used as a high-purity reference standard in studies of thrombin inhibition kinetics and structure-activity relationships (SAR).
• Pharmaceutical Development: Serves as a key intermediate or analytical standard in the R&D of novel anticoagulant and antithrombotic therapies.
• Diagnostic Reagents: Employed in the calibration and development of in-vitro diagnostic (IVD) assays for measuring thrombin activity or screening for coagulation disorders.
• Enzymology Studies: A crucial tool for investigating the specificity and mechanism of serine proteases beyond thrombin.
• Academic & Institutional Use: Utilized in university and research institute laboratories for fundamental research in biochemistry and vascular biology.

Basic Information

Product Name	N(Alpha)-Acetylhirudin(45-65)
CAS No.	107569-56-2
Molecular Formula	C96H147N27O31S2
Molecular Weight	~2243.5 g/mol
Synonyms	Acetyl-Hirudin(45-65); Nα-Acetylhirudin fragment 45-65; Hirudin(45-65), N(alpha)-acetyl-; Acetylated Hirudin Peptide (45-65); [Acetyl]-Hirudin45-65; Thrombin Inhibitor Peptide Fragment; Ac-Hirudin(45-65)
EINECS	Contact for details

Quality Control

Our N(Alpha)-Acetylhirudin(45-65) is produced under stringent conditions to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is supported by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.