Description

Hemoglobin Chicago is a specific, naturally occurring variant of hemoglobin, a critical oxygen-transporting metalloprotein found in red blood cells. This compound is of significant interest in biochemical and clinical research for studying hemoglobinopathies and oxygen affinity disorders. It is primarily utilized by researchers and diagnostic manufacturers in the fields of hematology, molecular biology, and clinical diagnostics to develop assays and reference materials.

Application

• Biochemical Research: Used as a reference standard in studies of hemoglobin structure, function, and genetic mutations.
• Clinical Diagnostics: Serves as a critical component in the development and calibration of diagnostic kits for detecting hemoglobin variants.
• Hematology Studies: Employed to investigate oxygen-binding properties and the pathophysiology of related blood disorders.
• Pharmaceutical Development: Acts as a model compound in research for novel therapeutics targeting hemoglobin-related diseases.
• Quality Control Material: Used by in-vitro diagnostic (IVD) manufacturers as a control material to ensure the accuracy of hemoglobin electrophoresis and chromatography systems.

Basic Information

Product Name	Hemoglobin Chicago
CAS No.	107497-29-0
Molecular Formula	C2952H4664N812O840S8Fe4
Molecular Weight	~64.5 kDa
Synonyms	Hb Chicago; Hemoglobin variant Chicago; Unstable hemoglobin Chicago; Hemoglobin ß-Chicago; Hemoglobin β-Chicago; Hb ß-Chicago; Hemoglobin (human beta Chicago variant); Hemoglobin, Chicago variant
EINECS	Contact for details

Quality Control

Our Hemoglobin Chicago is produced and handled under strict quality protocols to ensure batch-to-batch consistency and purity suitable for research applications. Each lot is characterized using advanced analytical techniques, including HPLC and electrophoresis, to confirm identity and assess purity relative to common hemoglobin variants. A comprehensive Certificate of Analysis (COA) detailing specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be prepared fresh and stored at 2-8°C for short-term use. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (HPLC/Electrophoresis)	Conforms to standard for Hemoglobin Chicago
Purity (by HPLC)	≥ 95% (relative to major hemoglobin variants)
Solubility	Soluble in water or appropriate buffer
Protein Content (Biuret)	≥ 90%
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.