Description

Bicyclo[1.1.1]pentane-1-carboxamide is a specialized, high-value chemical building block featuring the unique and highly strained bicyclo[1.1.1]pentane (BCP) core. This compound is of significant interest for its role in modulating the physicochemical properties of molecules, particularly in medicinal chemistry and advanced materials science. It serves as a critical intermediate for researchers and developers in the pharmaceutical, agrochemical, and material science industries seeking to incorporate three-dimensional, sp3-rich scaffolds into their target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in fragment-based drug discovery and bioisosteric replacement strategies to improve metabolic stability and solubility.
• Medicinal Chemistry: Used to incorporate the rigid, three-dimensional BCP scaffold into lead compounds, potentially enhancing binding affinity and selectivity while reducing planarity.
• Agrochemical Research: Intermediate in the development of new active ingredients with improved environmental and biological profiles.
• Advanced Material Synthesis: Precursor for creating polymers and specialty materials with unique mechanical or optical properties derived from the strained hydrocarbon framework.
• Chemical Biology: Employed as a probe or linker in the study of protein-ligand interactions and biochemical pathways.
• Academic & R&D: Fundamental research reagent for exploring new synthetic methodologies and the properties of strained organic molecules.

Basic Information

Product Name	Bicyclo[1.1.1]pentane-1-carboxamide
CAS No.	107474-98-6
Molecular Formula	C6H9NO
Molecular Weight	111.14 g/mol
Synonyms	1-Carbamoylbicyclo[1.1.1]pentane; BCP-Carboxamide; Bicyclo[1.1.1]pentanecarboxamide; (Bicyclo[1.1.1]pentan-1-yl)carboxamide; 1-Aminocarbonylbicyclo[1.1.1]pentane; BCP-NH2; 107474-98-6
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane-1-carboxamide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP and ISO standards for reliable and consistent supply to critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to minimize moisture uptake and ensure long-term stability. Recommended storage temperature is 2-8°C for prolonged periods.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.