Description

(p-Azidosalicylamido)Ethyl-1,3'-Dithiopropionic Acid is a specialized heterobifunctional crosslinking reagent containing both a photoactivatable aryl azide group and a cleavable disulfide bond. This compound matters for researchers and manufacturers requiring precise, reversible conjugation of biomolecules, such as proteins and peptides, under controlled conditions. It is primarily needed by the life sciences sector for applications in bioconjugation, affinity chromatography, and the development of diagnostic assays and targeted drug delivery systems.

Application

• Bioconjugation reagent for crosslinking proteins, peptides, and other biomolecules.
• Affinity chromatography ligand immobilization with cleavable linkers.
• Photoaffinity labeling studies to investigate protein-ligand interactions.
• Surface modification for biosensor and microarray development.
• Preparation of immunoconjugates for diagnostic and therapeutic research.
• Reversible immobilization of enzymes or catalysts in bioprocessing.
• Development of stimuli-responsive drug delivery systems utilizing disulfide cleavage.

Basic Information

Product Name	(p-Azidosalicylamido)Ethyl-1,3'-Dithiopropionic Acid
CAS No.	107426-70-0
Molecular Formula	C14H17N5O5S2
Molecular Weight	399.44 g/mol
Synonyms	N-[2-[3-[(2-Azido-4-hydroxybenzoyl)amino]propyldisulfanyl]ethyl]-4-azido-2-hydroxybenzamide; SASD; Sulfosuccinimidyl 2-[(7-azido-4-methylcoumarin-3-acetamido)ethyldithio]ethyl sulfone (related compound); Heterobifunctional crosslinker, aryl azide-disulfide; p-Azidosalicylamidoethyl dithiopropionate; Photo-cleavable crosslinking agent; Azido-salicylamide disulfide reagent
EINECS	Contact for details

Quality Control

Our (p-Azidosalicylamido)Ethyl-1,3'-Dithiopropionic Acid is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and functional group analysis. Certificates of Analysis (COA) detailing lot-specific results are available upon request to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.