Description

Heterochromatin-Specific Nonhistone Chromosomal Protein Hp-1 CAS NO 107283-02-3 is a specialized protein critical for the structural organization and functional regulation of heterochromatin within the cell nucleus. Its primary value lies in its role as a key epigenetic regulator, influencing gene silencing, chromatin compaction, and genome stability. This makes it an essential research reagent for molecular biologists, biochemists, and pharmaceutical developers focused on epigenetics, gene expression studies, and chromatin dynamics. High-purity preparations are vital for ensuring reproducible results in advanced biochemical assays and structural studies.

Application

• Epigenetics Research: Fundamental studies on heterochromatin formation, maintenance, and the mechanisms of gene silencing.
• Chromatin Biochemistry: Used in in vitro assays to investigate protein-protein and protein-DNA interactions within chromatin complexes.
• Drug Discovery Screening: Target protein for identifying and validating small molecules or biologics that modulate chromatin structure for therapeutic purposes (e.g., in oncology).
• Cellular & Molecular Biology: Essential reagent for experiments involving chromatin immunoprecipitation (ChIP), co-immunoprecipitation (Co-IP), and fluorescence microscopy.
• Structural Biology: Protein source for X-ray crystallography, NMR spectroscopy, or cryo-EM studies to elucidate the architecture of chromatin regulatory complexes.
• Diagnostic Development: Potential use as a component or target in assays designed to detect epigenetic alterations linked to specific diseases.

Basic Information

Item	Detail
Product Name	Heterochromatin-Specific Nonhistone Chromosomal Protein Hp-1
CAS No.	107283-02-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	HP1 Protein; Heterochromatin Protein 1; Chromobox Homolog; CBX Protein; HP1-alpha; HP1β; HP1γ; Heterochromatin-Associated Nonhistone Chromosomal Protein
EINECS	Contact for details

Quality Control

Our Heterochromatin-Specific Nonhistone Chromosomal Protein Hp-1 is produced under stringent conditions to ensure high purity, activity, and batch-to-batch consistency, critical for sensitive research applications. Quality is verified through a comprehensive suite of analytical techniques including SDS-PAGE, Western Blot, mass spectrometry, and functional activity assays. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, concentration, buffer composition, and storage specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at ≤ -20°C in small aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed properly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	Clear to slightly opalescent solution
Identification (SDS-PAGE/Western Blot)	Single band at expected molecular weight
Purity (SDS-PAGE, Densitometry)	≥ 90%
Protein Concentration	As specified on COA (typically 0.1 - 1.0 mg/mL)
Buffer Composition	Specified on COA (e.g., Tris, NaCl, Glycerol, DTT)
Biological Activity	Functional assay dependent (e.g., chromatin binding)
Endotoxin Level	< 1.0 EU/µg (for cell-based applications)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.