Description

Insulin, 3-(n-Phenylacetyl)- is a chemically modified derivative of the insulin hormone, specifically acylated at the B3 position with a phenylacetyl group. This modification is of significant interest in pharmaceutical research for studying insulin structure-activity relationships and developing novel therapeutic analogs with altered pharmacokinetic profiles. It serves as a critical intermediate and reference standard for researchers in the fields of endocrinology, diabetes research, and peptide-based drug discovery.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel insulin analogs with potential therapeutic applications.
• Biochemical Studies: Used to investigate the impact of specific amino acid modifications on insulin's receptor binding affinity and biological activity.
• Reference Standard: Serves as a high-purity analytical standard for quality control in the production of specialized insulin derivatives.
• Metabolic Disorder Research: A tool for academic and industrial labs studying diabetes, insulin signaling pathways, and hormone metabolism.
• Peptide Chemistry: An example of site-specific acylation for scientists developing conjugation and modification techniques for proteins and peptides.

Basic Information

Product Name	Insulin, 3-(n-Phenylacetyl)-
CAS No.	107161-05-7
Molecular Formula	C260H387N65O79S6
Molecular Weight	~5828.6 g/mol
Synonyms	3-(Phenylacetyl)-Insulin; N-Phenylacetyl-Insulin; Insulin B3-(Phenylacetyl); B3-Phenylacetyl Insulin; Insulin (Phe(B3)-acetyl); Insulin derivative (B3 acylated); [Phenylacetyl-B3]-Insulin
EINECS	Contact for details

Quality Control

Our Insulin, 3-(n-Phenylacetyl)- is produced and handled under strict quality protocols suitable for research applications. Each batch is characterized to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as purity (by HPLC), peptide content, and related substances are provided to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Peptide Content (UV)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Biological Activity	To be determined per customer method

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.