Description

Dipyridamole Di-o-B-D-Glucuronide is a key glucuronidated metabolite of the antiplatelet drug dipyridamole. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in bioanalytical method development and regulatory submission support.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantification of dipyridamole metabolites in biological matrices during clinical and non-clinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Used to investigate the metabolic pathways, clearance mechanisms, and bioavailability of dipyridamole.
• Bioanalytical Method Development: Essential for developing and validating sensitive and specific analytical methods, such as LC-MS/MS, for therapeutic drug monitoring and pharmacokinetic profiling.
• Impurity Profiling: Acts as an identified impurity standard in the quality control of dipyridamole active pharmaceutical ingredient (API) to ensure product purity and safety.
• Regulatory Compliance: Supports regulatory filings (e.g., for FDA, EMA) by providing definitive characterization of major human metabolites as required by ICH M3(R2) and related guidelines.

Basic Information

Product Name	Dipyridamole Di-o-B-D-Glucuronide
CAS No.	107136-95-8
Molecular Formula	C₃₆H₄₄N₈O₁₆
Molecular Weight	832.79 g/mol
Synonyms	Dipyridamole Diglucuronide; Persantine Diglucuronide; 2,2',2'',2'''-(4,8-Di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl))tetrakis(ethane-1,1-diyl) tetrakis(β-D-glucopyranosiduronic acid); RA-642; Dipyridamole Bisglucuronide; Dipyridamole Di-O-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Dipyridamole Di-o-B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.