Description

Human Oncostatin M (OSM) is a pleiotropic cytokine belonging to the interleukin-6 (IL-6) family, playing a critical role in modulating inflammatory responses, hematopoiesis, and tissue development. Its primary commercial value lies in its essential function as a high-purity research reagent for advanced cell biology, immunology, and oncology studies. This product is specifically targeted at biotechnology firms, academic research institutions, and pharmaceutical companies engaged in drug discovery and development for inflammatory diseases, cancer, and metabolic disorders.

Application

• Biomedical Research: Used as a key cytokine in cell culture to study signaling pathways, gene expression, and cellular differentiation in immune cells, hepatocytes, and fibroblasts.
• Drug Discovery & Target Validation: Essential for in vitro assays to screen and validate potential therapeutic compounds targeting the OSM/OSMR or LIFR/gp130 receptor complexes.
• Inflammation & Immunology Studies: Applied to investigate its role in chronic inflammatory conditions such as rheumatoid arthritis, inflammatory bowel disease, and asthma.
• Cancer Research: Utilized to explore the dual role of OSM in tumor progression and suppression, particularly in breast cancer, glioblastoma, and melanoma models.
• Stem Cell & Tissue Engineering: Employed to direct the differentiation of stem cells and to study its effects on extracellular matrix remodeling and tissue repair.
• Diagnostic Development: Serves as a reference standard or calibrator in the development of immunoassays (ELISA) for quantifying OSM levels in clinical samples.

Basic Information

Product Name	Human Oncostatin M
CAS No.	106956-32-5
Molecular Formula	C860H1342N232O252S10
Molecular Weight	Approx. 19,200 Da (monomeric, glycosylated form)
Synonyms	Oncostatin M; OSM; Oncostatin-M; MGC20461; IL-31; Interleukin-31; Cytokine OSM; Human OSM; Recombinant Human Oncostatin M; rhOSM; OSMR ligand
EINECS	Contact for details

Quality Control

Our Human Oncostatin M is manufactured under stringent conditions to ensure the highest standards of purity and biological activity, suitable for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, endotoxin levels, sterility, and biological potency. Quality is assured through compliance with relevant guidelines for recombinant protein production. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Upon reconstitution, aliquot and store at -70°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	> 95%
Purity (HPLC)	> 98%
Identification (Mass Spectrometry)	Consistent with theoretical molecular weight
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (Cell-based assay)	Contact for details
Sterility (Membrane Filtration)	Sterile
Formulation	Lyophilized from a sterile, filtered solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.