Description

1-Methoxy-2-(2,2,2-trifluoroethoxy)benzene is a specialized aromatic ether compound featuring a trifluoroethoxy side chain. This unique structure makes it a valuable intermediate and building block in advanced organic synthesis, particularly where the introduction of fluorine atoms is desired to modulate the properties of target molecules. It is primarily needed by pharmaceutical, agrochemical, and advanced materials research sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially those requiring fluorinated motifs for enhanced metabolic stability, bioavailability, or receptor binding affinity.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoroethoxy group can contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), influencing dielectric constant and charge transport properties.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, potentially altering surface energy, chemical resistance, and optical characteristics.
• Organic Synthesis Reagent: Acts as a protected or functionalized phenol derivative in complex multi-step synthetic routes across various fine chemical applications.
• Research & Development: Utilized in academic and industrial R&D laboratories for exploring new chemical reactions and creating novel fluorinated compounds.

Basic Information

Product Name	1-Methoxy-2-(2,2,2-Trifluoroethoxy)Benzene
CAS No.	106854-74-4
Molecular Formula	C9H9F3O2
Molecular Weight	206.16 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)anisole; 1-Methoxy-2-(2,2,2-trifluoroethoxy)benzene; o-(Trifluoroethoxy)anisole; Benzene, 1-methoxy-2-(2,2,2-trifluoroethoxy)-; 2-Methoxyphenyl 2,2,2-trifluoroethyl ether; Guaifenesin Trifluoroethyl Ether (related derivative); TFEE-Anisole
EINECS	Contact for details

Quality Control

Our 1-Methoxy-2-(2,2,2-trifluoroethoxy)benzene is produced under a strict quality management system. Each batch undergoes rigorous analytical testing including HPLC, GC, and NMR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates for pharmaceutical and advanced material synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and open flame. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.