Description

2,6-Difluoro-β-Oxo-Benzenepropanoic Acid Methyl Ester is a high-purity fluorinated aromatic ester building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a β-keto ester moiety and difluoro substitution, makes it a versatile precursor for constructing complex heterocycles and active pharmaceutical ingredients (APIs). This compound is primarily sought by research and development chemists and process scale-up teams within the pharmaceutical and agrochemical industries. Its precise reactivity profile enables the synthesis of novel compounds with potential biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used as a building block for developing novel herbicides and pesticides, where the fluorine atoms can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or intermediate in the development of specialty polymers and advanced materials with specific electronic or surface properties.
• Organic Synthesis Reagent: Employed in Claisen condensations, Michael additions, and cyclization reactions to construct complex molecular frameworks in academic and industrial R&D settings.
• Fluorine Chemistry Studies: A valuable compound for investigating the effects of fluorine substitution on reaction kinetics and molecular conformation in synthetic chemistry.

Basic Information

Product Name	2,6-Difluoro-β-Oxo-Benzenepropanoic Acid Methyl Ester
CAS No.	106816-08-4
Molecular Formula	C10H8F2O3
Molecular Weight	214.17 g/mol
Synonyms	Methyl 2,6-difluoro-β-oxobenzenepropanoate; 3-(2,6-Difluorophenyl)-3-oxopropanoic acid methyl ester; Methyl 3-(2,6-difluorophenyl)-3-oxopropanoate; 2,6-Difluorobenzoylacetic acid methyl ester; Methyl (2,6-difluorobenzoyl)acetate; 106816-08-4; Benzenepropanoic acid, 2,6-difluoro-β-oxo-, methyl ester
EINECS	Contact for details

Quality Control

Every batch of 2,6-Difluoro-β-Oxo-Benzenepropanoic Acid Methyl Ester is manufactured under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and reactivity. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.