Description

Boc-Thr(Po3Ph2)-Oh is a specialized, protected amino acid derivative featuring a phosphonic acid group, widely utilized as a key building block in advanced organic synthesis. Its primary value lies in enabling the precise introduction of phosphonate functionality into peptides and other bioactive molecules, which is crucial for modulating biological activity and stability. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors engaged in developing novel therapeutics, enzyme inhibitors, and chemical probes.

Application

• Pharmaceutical Intermediate: A critical building block for the solid-phase and solution-phase synthesis of phosphonopeptides and peptidomimetics with potential therapeutic applications.
• Protease Inhibitor Development: Used to create transition-state analog inhibitors that target various proteases, relevant for drug discovery in virology, oncology, and inflammatory diseases.
• Chemical Biology Tool: Incorporation into peptides to study phosphorylation-dependent signaling pathways and protein-protein interactions.
• Agrochemical Research: Serves as a precursor in the synthesis of compounds with herbicidal or plant growth regulation activity.
• Material Science: Potential use in creating functionalized surfaces or polymers with specific metal-chelating properties.

Basic Information

Product Name	Boc-Thr(Po3Ph2)-Oh
CAS No.	106815-65-0
Molecular Formula	C₁₄H₂₂NO₈P₂
Molecular Weight	409.28 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-(diphenylphosphono)-L-threonine; Boc-L-threonine(O-diphenylphosphonate); (2S,3R)-3-[[(Diphenoxyphosphoryl)oxy]-2-[(tert-butoxycarbonyl)amino]butanoic acid; Boc-Thr(PO(Ph)₂)-OH; Boc-Protected Phosphonothreonine; tert-Butyloxycarbonyl-O-diphenylphosphono-L-threonine; L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-, (phenylmethyl) ester, 4-(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our Boc-Thr(Po3Ph2)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production use. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development under cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.