Description

(R)-tert-Butyl 2-Oxoazepan-3-Ylcarbamate CAS NO 106691-72-9 is a high-purity chiral building block and advanced pharmaceutical intermediate characterized by its azepanone core and protected amine functionality. This compound is of significant value for the synthesis of complex bioactive molecules, particularly in the development of protease inhibitors and other therapeutic agents. It is primarily needed by research institutions, custom synthesis houses, and pharmaceutical companies engaged in the development of new chemical entities and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly those targeting enzymatic pathways.
• Protease Inhibitor Development: Serves as a core scaffold or precursor for molecules designed to inhibit specific proteases, relevant in antiviral, anticancer, and anti-inflammatory research.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational restraint and modified backbone structures into peptide-based drug designs to enhance stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective chemical reactions to construct complex molecules with high enantiomeric purity.
• Chemical Biology & Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and niche APIs.

Basic Information

Product Name	(R)-tert-Butyl 2-Oxoazepan-3-Ylcarbamate
CAS No.	106691-72-9
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	(3R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-azepanone; (R)-3-[(tert-Butoxycarbonyl)amino]azepan-2-one; (R)-3-(Boc-amino)caprolactam; (R)-tert-Butyl (2-oxoazepan-3-yl)carbamate; (R)-Boc-3-amino-ε-caprolactam; (R)-N-Boc-3-amino-2-azepanone; (R)-3-Amino-2-azepanone tert-butylcarbamate; tert-Butyl (3R)-2-oxoazepane-3-carboxylate (related isomer)
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 2-Oxoazepan-3-Ylcarbamate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from HPLC, chiral analysis, NMR, and mass spectrometry. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.