Description

(Gln11)-Amyloid β-Protein (1-28) CAS NO 106686-61-7 is a synthetic peptide fragment of the amyloid β-protein, specifically modified with a glutamine residue at position 11. This peptide is a critical research tool for studying the molecular mechanisms of amyloid aggregation and neurotoxicity, which are central to Alzheimer's disease pathology. It is essential for researchers and pharmaceutical developers in the fields of neuroscience, biochemistry, and drug discovery who require high-purity, well-characterized peptides for in vitro and in vivo studies.

Application

• Biomedical Research: Fundamental studies on the aggregation kinetics, structure, and toxicity of amyloid beta peptides.
• Drug Discovery Screening: Used as a target or reagent in high-throughput assays to identify potential inhibitors of amyloid beta aggregation.
• Antibody & Diagnostic Development: Serves as an antigen for the production and characterization of antibodies specific to amyloid beta epitopes, aiding in diagnostic test development.
• Structural Biology: NMR and X-ray crystallography studies to elucidate the three-dimensional conformation of amyloid beta fragments and their interactions.
• Cell Culture & Toxicology: Application in neuronal cell culture models to investigate peptide-induced cytotoxicity and cellular pathways.
• Biophysical Characterization: Analysis of peptide behavior in solution using techniques like circular dichroism (CD) and fluorescence spectroscopy.

Basic Information

Product Name	(Gln11)-Amyloid β-Protein (1-28)
CAS No.	106686-61-7
Molecular Formula	C140H218N42O43
Molecular Weight	3145.5 g/mol
Synonyms	Abeta (1-28) (Gln11); Amyloid β-Protein (1-28) (Gln11); Aβ(1-28) Gln11; DAEFRHDSGYEVHHQKLVFFAEDVGSNK; β-Amyloid (1-28), Gln11-substituted; Amyloid Beta Peptide (1-28) with Glutamine at position 11
EINECS	Contact for details

Quality Control

Our (Gln11)-Amyloid β-Protein (1-28) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to quality management principles aligned with GMP guidelines for active pharmaceutical ingredients (APIs) where applicable, ensuring traceability and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.