Description

D-Proline, 1-Acetyl-4-Hydroxy-, (4S)-Rel- (9Ci) is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, stereochemically defined intermediates to streamline asymmetric synthesis and drug discovery workflows.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in the development of protease inhibitors, enzyme modulators, and other therapeutic agents.
• Asymmetric Synthesis: Used as a chiral auxiliary or a starting material in stereoselective reactions to construct molecules with defined three-dimensional architecture.
• Peptidomimetics Research: Incorporated into peptide analogs to study structure-activity relationships, enhance metabolic stability, or modify biological activity.
• Agrochemical Development: Serves as a building block for creating novel, chiral active ingredients for crop protection products.
• Catalyst Ligand Synthesis: Potential precursor for the development of novel chiral ligands used in asymmetric catalysis.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to probe biological pathways and mechanisms.

Basic Information

Product Name	D-Proline, 1-Acetyl-4-Hydroxy-, (4S)-Rel- (9Ci)
CAS No.	106564-72-1
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	(4S)-1-Acetyl-4-hydroxy-D-proline; (4S)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid; rel-(4S)-1-Acetyl-4-hydroxy-D-proline; 1-Acetyl-4-hydroxy-D-proline; 4-Hydroxy-1-acetyl-D-proline; D-1-Acetyl-4-hydroxyproline; (2R,4S)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our D-Proline, 1-Acetyl-4-Hydroxy-, (4S)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.