Description

Chromogranin A (272-288) (Porcine) is a defined peptide fragment derived from the larger chromogranin A protein, a key member of the granin family of acidic secretory proteins. This specific sequence is of significant interest in neuroendocrine and cardiovascular research for its role as a precursor to biologically active peptides like pancreastatin and catestatin. It serves as a critical research tool for scientists and pharmaceutical developers studying secretory granule function, hormone processing, and related disease mechanisms. The compound is supplied with the CAS registry number 106507-61-3.

Application

• Biomedical Research: Used as a standard or antigen in studies investigating the biosynthesis, processing, and secretion of chromogranin A and its derived peptides.
• Antibody Production: Acts as an immunogen for generating specific polyclonal or monoclonal antibodies targeting the Chromogranin A (272-288) region.
• Assay Development: Employed in the development and validation of immunoassays (ELISA, RIA) to detect and quantify chromogranin A or its fragments in biological samples.
• Neuroendocrine Studies: Fundamental for research into neuroendocrine tumors, where chromogranin A is a well-established biomarker.
• Cardiovascular Research: Investigated for its role in blood pressure regulation and catecholamine release through its derivative, catestatin.
• Cell Biology: Utilized to probe the mechanisms of granule formation and regulated secretory pathways in endocrine and neuronal cells.

Basic Information

Product Name	Chromogranin A (272-288) (Porcine)
CAS No.	106507-61-3
Molecular Formula	C91H147N27O28S
Molecular Weight	2095.4 g/mol
Synonyms	Porcine Chromogranin A Fragment 272-288; CgA (272-288), porcine; Chromogranin A Peptide (272-288); CGA 272-288; pCgA(272-288); Catestatin precursor fragment; Chromogranin A-derived peptide; RKRS-5; H-Leu-Arg-Pro-Ala-Leu-Glu-Glu-Ser-Pro-Ala-Glu-Glu-Pro-Glu-Leu-Ala-Gln-OH
EINECS	Contact for details

Quality Control

Our Chromogranin A (272-288) (Porcine) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, critical for reproducible research outcomes. Each lot undergoes comprehensive analytical characterization, including reversed-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. A detailed Certificate of Analysis (COA) is provided, documenting the purity, amino acid analysis, and other relevant specifications. We adhere to rigorous quality management practices suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Net Peptide Content	≥ 75%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.