Description

Osteopontin CAS NO 106441-73-0 is a phosphorylated glycoprotein and a key member of the SIBLING (Small Integrin-Binding Ligand, N-linked Glycoprotein) family, playing a critical role in cell-matrix interactions and biomineralization processes. Its significance lies in its multifunctional nature, influencing cellular adhesion, migration, signaling, and immune modulation. This makes it an essential research reagent and a potential therapeutic target for industries focused on biomedical research, bone biology studies, and advanced material science.

Application

• Biomedical Research: Used as a critical reagent in studies of bone metabolism, cancer metastasis, immune response, and inflammatory diseases.
• Cell Culture & Tissue Engineering: Employed as a coating protein to promote cell adhesion, proliferation, and differentiation in stem cell research and 3D tissue scaffolds.
• Diagnostic Development: Serves as a standard or antigen in the development of immunoassays (ELISA) and diagnostic kits for detecting Osteopontin levels in biological samples.
• Biomaterial Science: Incorporated into composite materials to enhance the biocompatibility and osteointegration properties of bone grafts and dental implants.
• Pharmaceutical R&D: Investigated as a biomarker and a potential drug target for conditions like osteoporosis, atherosclerosis, and chronic kidney disease.
• Basic Biochemical Studies: Utilized in protein-protein interaction studies, signal transduction pathway analysis, and structural biology research.

Basic Information

Product Name	Osteopontin
CAS No.	106441-73-0
Molecular Formula	Contact for details
Molecular Weight	Approx. 44-75 kDa (isoform-dependent)
Synonyms	Secreted Phosphoprotein 1 (SPP1); Bone Sialoprotein I (BSP-1); Early T-Lymphocyte Activation 1 (η-1); Urinary Stone Protein (Uropontin); 2ar; Ric; Spp-1; BNSP; BNSPII; PSEC0156
EINECS	Contact for details

Quality Control

Our Osteopontin is produced and handled under stringent quality management protocols. Each batch undergoes rigorous analytical testing, including purity assessment by SDS-PAGE and HPLC, to ensure consistency and biological activity. Certificates of Analysis (COA) detailing specific test results are available upon request to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or desiccated conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Complies
Purity (HPLC)	≥ 90%
Protein Content (BCA)	≥ 95% of total mass
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (Cell Adhesion)	Functional
Solubility	Soluble in PBS or cell culture medium

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.