Description

Technetium Tc-99M Siboroxime is a radiopharmaceutical compound used as a diagnostic imaging agent. Its primary value lies in its ability to bind to cerebral perfusion sites, enabling the non-invasive assessment of regional cerebral blood flow. This product is essential for nuclear medicine departments, research institutions, and pharmaceutical companies involved in the development and application of brain imaging diagnostics. It is a critical tool for investigating conditions such as stroke, epilepsy, and dementia.

Application

• Myocardial Perfusion Imaging (MPI): Used in single-photon emission computed tomography (SPECT) to evaluate blood flow to the heart muscle, aiding in the diagnosis of coronary artery disease.
• Cerebral Perfusion Imaging: Primary application for assessing regional cerebral blood flow in patients with suspected stroke, transient ischemic attack (TIA), or other cerebrovascular disorders.
• Neurological Disorder Research: A vital tool in clinical research for studying brain function and perfusion changes associated with epilepsy, Alzheimer's disease, and other dementias.
• Radiopharmaceutical Kit Formulation: Serves as the active pharmaceutical ingredient (API) in the preparation of sterile, pyrogen-free diagnostic kits for hospital radiopharmacies.
• Oncology Imaging: Can be utilized in certain protocols to assess tumor perfusion and viability.

Basic Information

Product Name	Technetium Tc-99M Siboroxime
CAS No.	106417-28-1
Molecular Formula	C24H48N6O4Tc
Molecular Weight	Contact for details
Synonyms	Tc-99m Siboroxime; Technetium (99mTc) Siboroxime; Bicisate (99mTc); Neurolite (Brand Name); Ethyl Cysteinate Dimer (ECD), Tc-99m labeled; d,l-HMPAO analog; Tc-99m ECD; RP-444 (Research Code)
EINECS	Contact for details

Quality Control

Technetium Tc-99M Siboroxime is manufactured and controlled under strict quality systems. Each batch is tested to ensure it meets stringent specifications for radiochemical purity, radionuclidic purity, pH, sterility, and apyrogenicity, in accordance with relevant pharmacopoeial standards (e.g., USP monographs for radiopharmaceuticals). A comprehensive Certificate of Analysis (COA), detailing all release specifications and test results, is provided with every shipment to guarantee product integrity and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature or as specified on the label. Due to its radioactive nature and sensitivity to oxidation, it must be handled and stored according to radiation safety protocols and used within the validated shelf-life post-preparation. Specific storage and handling instructions are provided with the product documentation.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC/Radio-TLC)	Conforms to reference standard
pH	5.0 - 7.5
Radiochemical Purity (HPLC)	≥ 90.0%
Radionuclidic Purity (Gamma Spectroscopy)	≥ 99.9% Tc-99m
Chemical Purity (HPLC)	Meets established limits
Sterility Test (Membrane Filtration)	Sterile
Bacterial Endotoxins (LAL)	< 175 EU/Vial

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.