Description

Poloxamer 188 Crs is a high-purity, non-ionic triblock copolymer of poly(ethylene oxide) and poly(propylene oxide) widely recognized for its superior surfactant and solubilizing properties. This pharmaceutical-grade excipient is critical for enhancing the stability, bioavailability, and safety of injectable and oral drug formulations. It is an essential material for pharmaceutical manufacturers, biotechnology companies, and research institutions developing parenteral solutions, solid dispersions, and advanced drug delivery systems.

Application

• Pharmaceutical Excipient: Primarily used as a solubilizer, emulsifier, and stabilizer in injectable formulations, including intravenous and intramuscular preparations.
• Cryoprotectant: Employed in cell culture media and bioprocessing to protect biological cells from damage during freeze-thaw cycles.
• Wetting Agent & Dispersant: Enhances the wettability and dispersion of poorly soluble active pharmaceutical ingredients (APIs) in solid and liquid dosage forms.
• Biomaterial Coating: Used to modify surface properties of medical devices and nanoparticles to reduce protein adsorption and improve biocompatibility (stealth effect).
• Research & Development: A key reagent in life science research for membrane studies, protein purification, and as a cell membrane fusogen.

Basic Information

Product Name	Poloxamer 188 Crs
CAS No.	106392-12-5
Molecular Formula	CnH2n+1O(C2H4O)a(C3H6O)b(C2H4O)aH
Molecular Weight	~8400 - 9500 g/mol (typical average)
Synonyms	Poloxamer 188; Pluronic F68; Lutrol F68; Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Oxirane, methyl-, polymer with oxirane, block; Polyoxyethylene-polyoxypropylene block copolymer (EO/PO block copolymer); Monolan PB 68/50; Synperonic PE/F68.
EINECS	Contact for details

Quality Control

Our Poloxamer 188 Crs is manufactured and tested to meet the stringent requirements of global pharmacopoeial standards, including USP-NF and Ph. Eur. Each batch undergoes rigorous quality testing to ensure compliance with specifications for identity, purity, and performance. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and supply chain integrity for GMP-regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white waxy solid or flakes
Identification (IR)	Conforms
Assay (Oxyethylene Content)	79.9% - 83.7%
pH (1% Solution)	5.0 - 7.5
Water Content	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.4%
Cloud Point (1% Aq. Solution)	>100 °C
Average Molecular Weight	~8400 - 9500

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.