Description

ω-Conotoxin Gvia is a highly specific and potent peptide neurotoxin derived from the venom of marine cone snails. This compound is a crucial research tool for studying N-type voltage-gated calcium channels (Cav2.2) in neuronal signaling and pain pathways. It is primarily utilized by pharmaceutical researchers, neuroscientists, and academic institutions engaged in neuroscience, pharmacology, and analgesic drug discovery programs.

Application

• Neuroscience Research: Selective blockade of N-type calcium channels (Cav2.2) to study synaptic transmission, neurotransmitter release, and neuronal excitability.
• Pain Pathway Analysis: Investigation of the role of Cav2.2 channels in nociception and chronic pain models, serving as a reference standard in analgesic research.
• Pharmacological Tool: Used in in vitro assays (e.g., patch-clamp electrophysiology) and in vivo studies to validate channel function and specificity.
• Drug Discovery & Development: A key biological reagent for screening and characterizing novel compounds targeting calcium channels for therapeutic applications.
• Biochemical Studies: Employed in receptor binding studies and structure-activity relationship (SAR) research due to its high affinity and selectivity.
• Academic & Institutional Research: Essential for fundamental research in cellular and molecular biology departments worldwide.

Basic Information

Product Name	ω-Conotoxin Gvia
CAS No.	106375-28-4
Molecular Formula	C98H150N30O29S6
Molecular Weight	~2350.7 g/mol
Synonyms	ω-Conotoxin GVIA; Conotoxin GVIA; ω-Conotoxin GVIA; CgVIA; SNX-124; N-type Calcium Channel Blocker ω-Conotoxin; ω-CTx-GVIA; ω-CgTx-GVIA
EINECS	Contact for details

Quality Control

Our ω-Conotoxin Gvia is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and bioactivity. We adhere to high-purity standards suitable for research use, with specifications typically meeting or exceeding requirements for pharmacological and biochemical applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch (typically nM range for N-type Ca2+ channels)
Solubility	Soluble in aqueous buffers (e.g., PBS, saline) or dilute acetic acid
Endotoxin Level	< 1.0 EU/μg (where applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.