Description

6-Desfluoro-6-Hydroxy Risperidone is a key pharmaceutical intermediate and metabolite of the antipsychotic drug risperidone. This compound is of significant importance in the research, development, and quality control of neuroleptic medications. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions involved in the synthesis of active pharmaceutical ingredients (APIs) and the study of drug metabolism.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of risperidone and related antipsychotic compounds.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in pharmaceutical quality control laboratories.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism and activity profile of risperidone.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of risperidone API during manufacturing.
• Biochemical Research: Used in studies investigating the mechanism of action and receptor binding affinity of atypical antipsychotics.

Basic Information

Product Name	6-Desfluoro-6-Hydroxy Risperidone
CAS No.	106266-11-9
Molecular Formula	C23H27FN4O2
Molecular Weight	410.49 g/mol
Synonyms	9-Hydroxyrisperidone; Risperidone Metabolite 9-Hydroxy; Paliperidone Related Compound A; 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, 9-Hydroxy; 9-OH-Risperidone
EINECS	Contact for details

Quality Control

Our 6-Desfluoro-6-Hydroxy Risperidone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific pharmacopeial or internal standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.