Description

3-Oxo-3-(4-Trifluoromethylphenyl)Propionic Acid Ethyl Ester is a high-value trifluoromethylated aromatic β-ketoester, serving as a versatile and critical building block in advanced organic synthesis. Its molecular architecture, featuring both a reactive ketoester moiety and a stable, lipophilic trifluoromethylphenyl group, makes it indispensable for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, particularly those requiring the trifluoromethyl group for enhanced metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and insecticides where the CF₃ group improves lipophilicity and biological activity.
• Material Science Research: Used in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorinated components.
• Chemical Research & Development: Serves as a substrate for novel organic reactions, including Claisen condensations, Michael additions, and cyclization reactions to form heterocycles.
• Fluorine Chemistry Studies: An important compound for investigating the influence of fluorine atoms on chemical reactivity and physical properties in molecular design.

Basic Information

Product Name	3-Oxo-3-(4-Trifluoromethylphenyl)Propionic Acid Ethyl Ester
CAS No.	106263-53-0
Molecular Formula	C₁₂H₁₁F₃O₃
Molecular Weight	260.21 g/mol
Synonyms	Ethyl 3-oxo-3-[4-(trifluoromethyl)phenyl]propanoate; Ethyl 4,4,4-trifluoroacetoacetate-4-trifluoromethylphenyl; 3-Oxo-3-(4-trifluoromethylphenyl)propionic acid ethyl ester; 1-Ethoxy-1-oxo-3-[4-(trifluoromethyl)phenyl]propan-2-one; Ethyl (4-trifluoromethylbenzoyl)acetate; 4-(Trifluoromethyl)phenacyl acetate ethyl ester; TFMPA ethyl ester; β-Keto ester of 4-trifluoromethylbenzoic acid
EINECS	Contact for details

Quality Control

Our 3-Oxo-3-(4-Trifluoromethylphenyl)Propionic Acid Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.