Description

Thymidine Glycol 5'-Triphosphate is a modified nucleotide triphosphate analog where the thymidine base contains a glycol moiety. This compound is a critical reagent in advanced biochemical research, particularly for studying oxidative DNA damage and repair mechanisms. It is essential for researchers and manufacturers in the fields of molecular biology, diagnostics, and pharmaceutical development who require high-purity nucleotide derivatives for enzymatic studies and probe synthesis.

Application

• Substrate for DNA Polymerases: Used in enzymatic assays to study the incorporation of oxidized nucleotides and the fidelity of DNA synthesis.
• Oxidative Damage Research: A vital tool for investigating the biological consequences and repair pathways of oxidative DNA lesions.
• Probe Synthesis: Employed in the enzymatic labeling of nucleic acid probes for sensitive detection methods.
• Biochemical Standard: Serves as a reference standard in analytical methods like HPLC and mass spectrometry for quantifying DNA damage products.
• Enzyme Kinetics Studies: Utilized to determine the kinetic parameters of repair enzymes such as glycosylases and nucleases.
• Diagnostic Assay Development: Incorporated into diagnostic kits designed to detect specific DNA repair enzyme activities.

Basic Information

Product Name	Thymidine Glycol 5'-Triphosphate
CAS No.	106094-52-4
Molecular Formula	C15H24N3O18P3
Molecular Weight	627.26 g/mol
Synonyms	5'-O-({Hydroxy[(hydroxy{[(2R,3S,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)-2,3-dihydroxyoxolan-3-yl]methoxy})phosphoryl]oxy}phosphoryl)thymidine glycol; dTgTP; (5'R)-5',8-Cyclo-2'-deoxyguanosine 5'-triphosphate; Thymine glycol triphosphate; 5,6-Dihydroxy-5,6-dihydrothymidine 5'-triphosphate; Oxidized dTTP; TG-TP
EINECS	Contact for details

Quality Control

Our Thymidine Glycol 5'-Triphosphate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to ISO 9001 quality management standards, and our production environment is designed to meet the rigorous demands of biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Biological Activity	Suitable for enzyme incorporation assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.