Description

(R)-1-Methacryloylpyrrolidine-2-Carboxylic Acid is a high-value, chiral building block featuring both a polymerizable methacrylate group and a carboxylic acid functionality. This compound is essential for the synthesis of advanced materials and pharmaceuticals where stereochemistry and functional group density are critical. It is primarily sought by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries for creating chiral stationary phases, drug conjugates, and functional monomers.

Application

• Chiral Stationary Phase (CSP) Synthesis: A key intermediate for manufacturing high-performance liquid chromatography (HPLC) columns used in enantiomer separation.
• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of chiral active pharmaceutical ingredients (APIs) and prodrugs.
• Functional Polymer Monomer: Used to introduce chiral centers and carboxylic acid groups into polymers for specialized coatings, hydrogels, and responsive materials.
• Agrochemical Research: Employed in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Acts as a precursor for creating chiral ligands used in asymmetric catalysis.
• Bioconjugation and Linker Chemistry: Utilized for attaching drug molecules or probes to polymers, surfaces, or biomolecules via its reactive handles.

Basic Information

Product Name	(R)-1-Methacryloylpyrrolidine-2-Carboxylic Acid
CAS No.	106089-24-1
Molecular Formula	C9H13NO3
Molecular Weight	183.21 g/mol
Synonyms	(R)-1-Methacryloyl-2-pyrrolidinecarboxylic acid; (R)-N-Methacryloylproline; (R)-1-[(2-Methyl-1-oxo-2-propen-1-yl)]-2-pyrrolidinecarboxylic acid; (R)-N-Methacryloylpyrrolidine-2-carboxylic acid; (R)-MPA; (R)-Methacryloylproline; (R)-1-Methacryloyl-L-proline; (R)-N-Methacryloyl-L-proline
EINECS	Contact for details

Quality Control

Our (R)-1-Methacryloylpyrrolidine-2-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality, enantiomeric excess, and batch-to-batch reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.