Description

Phenacetin-Ring-Ul-14C is a carbon-14 radiolabeled analog of the analgesic compound phenacetin, specifically labeled on the aromatic ring. This product is essential for advanced metabolic and pharmacokinetic studies, providing researchers with a precise tracer to investigate drug disposition pathways. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions conducting ADME (Absorption, Distribution, Metabolism, and Excretion) research and analytical method development.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to quantitatively track the absorption, distribution, metabolism, and excretion of phenacetin and related compounds in preclinical models.
• Metabolite Identification and Profiling: Facilitates the detection, isolation, and structural elucidation of metabolite(s) formed from the phenacetin core structure using advanced analytical techniques like LC-MS and radio-HPLC.
• Mass Balance Studies: Enables precise quantification of total drug-related material recovery in excreta and tissues for regulatory submission packages.
• Enzyme Reaction Phenotyping: Serves as a selective substrate probe to study the activity and contribution of specific cytochrome P450 isoforms (e.g., CYP1A2) involved in its metabolism.
• Analytical Reference Standard: Acts as an internal standard or reference material for developing and validating sensitive bioanalytical assays in complex biological matrices.
• Environmental Fate Studies: Applied in ecological research to trace the environmental breakdown and transformation pathways of phenacetin-related chemical structures.

Basic Information

Product Name	Phenacetin-Ring-Ul-14C
CAS No.	105931-34-8
Molecular Formula	C10H13NO2 (Ring-Ul-14C)
Molecular Weight	~179.2 g/mol (exact mass depends on 14C enrichment)
Synonyms	N-(4-Ethoxyphenyl)acetamide (Ring-Ul-14C); 4'-Ethoxyacetanilide-14C; Acetophenetidin-14C; [Ring-U-14C]Phenacetin; 1-Acetamido-4-ethoxybenzene (Ring-Ul-14C); p-Acetophenetidide-14C; p-Ethoxyacetanilide-14C
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled compounds is manufactured and analyzed under strict quality systems to ensure radiochemical purity, chemical purity, and specific activity meet the stringent requirements of research applications. Comprehensive analysis is performed using HPLC with UV and radiometric detection, supported by spectroscopic techniques. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, radioactivity concentration, and specific activity. Our quality commitment aligns with GLP (Good Laboratory Practice) principles for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures, typically between 2°C and 8°C (refrigerated) or as specified on the label and COA to maintain stability. The product is light-sensitive and should be stored away from light. Handle and store in accordance with all applicable radiation safety regulations for 14C-labeled materials.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Specific Activity	Customizable (mCi/mmol range)
Radioactivity Concentration	As per customer requirement
Solvent (if supplied as solution)	Specified inert solvent (e.g., Ethanol, Acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.