Description

Delta(2-89)-Tissue Plasminogen Activator CAS NO 105913-11-9 is a truncated, recombinant variant of the human tissue plasminogen activator (tPA), a key serine protease involved in the fibrinolytic system. This engineered form is critical for research and development in thrombolytic therapy, offering a model for studying clot dissolution mechanisms and designing next-generation pharmaceuticals. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies focused on cardiovascular disease, hemostasis, and novel therapeutic protein engineering.

Application

• Biopharmaceutical R&D: Serves as a reference standard and active ingredient in the development of novel thrombolytic (clot-busting) drugs.
• Enzymology & Biochemical Research: Used to study the kinetics, specificity, and inhibition of the plasminogen activation pathway in controlled in vitro systems.
• Cardiovascular Disease Modeling: Employed in preclinical research to investigate mechanisms of acute ischemic stroke, myocardial infarction, and pulmonary embolism.
• Assay Development & Calibration: Acts as a critical component in the development and validation of diagnostic assays measuring fibrinolytic activity.
• Structural Biology Studies: Provides material for X-ray crystallography, NMR, and other techniques to elucidate structure-function relationships in tPA variants.
• Cell Culture & Tissue Engineering: Applied in research exploring the role of fibrinolysis in cellular migration, tissue remodeling, and wound healing models.

Basic Information

Product Name	Delta(2-89)-Tissue Plasminogen Activator
CAS No.	105913-11-9
Molecular Formula	C2560H3924N746O781S42
Molecular Weight	~57.5 kDa
Synonyms	Delta(2-89)-tPA; tPA (2-89); Truncated Tissue Plasminogen Activator; Recombinant tPA variant; Alteplase fragment; Plasminogen activator, tissue-type, delta(2-89); Fibrinokinase (variant); rt-PA (2-89); EC 3.4.21.68 (variant)
EINECS	Contact for details

Quality Control

Our Delta(2-89)-Tissue Plasminogen Activator is produced and controlled under stringent quality systems. Each batch is characterized for identity, purity, and biological activity using advanced analytical techniques. Certificates of Analysis (COA) detailing specifications such as purity by HPLC, endotoxin levels, and specific activity are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under anhydrous conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE)	≥ 95%
Purity (RP-HPLC)	≥ 98.0%
Specific Activity	≥ 500,000 IU/mg
Endotoxin	< 1.0 EU/μg
Protein Content (UV)	≥ 90% of label claim
Solubility	Soluble in aqueous buffers
Residual Moisture (KF)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.