Description

Neurokinin B, Pro(2)-Trp(6,8)-Nle(10)- is a synthetic, biologically active peptide analog of the endogenous neurokinin B (NKB) tachykinin. This compound is a critical research tool for investigating the role of the neurokinin-3 receptor (NK3R) in physiological and pathological processes. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on neuroscience, endocrinology, and drug discovery. The peptide's specific modifications enhance its stability and receptor interaction profile, making it invaluable for in vitro and in vivo studies.

Application

• Neuroscience Research: Used as a selective agonist to study the function of the NK3 receptor in the central and peripheral nervous systems.
• Endocrinology Studies: Investigates the role of NKB in the regulation of hormone secretion, particularly in the hypothalamic-pituitary-gonadal axis.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool for screening and validating novel NK3R antagonists or agonists.
• Physiological Pathway Analysis: Elucidates signaling pathways involved in pain transmission, inflammation, and smooth muscle contraction.
• Academic & Institutional Research: Supports basic scientific research in university and government laboratories.
• Biomarker Research: Aids in studies exploring NKB as a potential biomarker for certain disease states.

Basic Information

Product Name	Neurokinin B, Pro(2)-Trp(6,8)-Nle(10)-
CAS No.	105869-12-3
Molecular Formula	C59H81N15O10S
Molecular Weight	1184.4 g/mol
Synonyms	Pro(2)-Trp(6,8)-Nle(10)-Neurokinin B; [Pro2,Trp6,8,Nle10]-NKB; NKB (2-10) analog; Tachykinin 3 agonist; NK3 Receptor Agonist; Neurokinin B fragment 2-10 analog; [pGlu6,Pro9]-Substance P (6-11); (2-10)-Neurokinin B, Pro2,Trp6,8,Nle10-
EINECS	Contact for details

Quality Control

Our Neurokinin B, Pro(2)-Trp(6,8)-Nle(10)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is characterized using advanced analytical techniques including HPLC, MS, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Confirmed by functional assay (e.g., calcium flux)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.