Description

8-Fluoro-4H-Thieno[3,2-C]Chromene-2-Carboxylic Acid is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique molecular scaffold, combining a chromene core with a thiophene ring and a carboxylic acid handle, makes it a versatile precursor for developing novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating new molecules with targeted properties. The CAS number for this compound is 105799-81-3.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, or insecticides, leveraging the bioactivity of the fluorinated chromene-thiophene structure.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the synthesis of advanced polymers, liquid crystals, or organic electronic materials.
• Chemical Biology Probe Development: Utilized to create fluorescent tags or molecular probes for studying biological processes and enzyme interactions.
• Academic & Contract Research: Employed in universities and CROs (Contract Research Organizations) for methodological studies and exploring new chemical spaces in heterocyclic chemistry.
• Scale-up & Process Chemistry: Supplied for route scouting, optimization, and kilogram-scale production under cGMP guidelines for clinical trial material synthesis.

Basic Information

Item	Details
Product Name	8-Fluoro-4H-Thieno[3,2-C]Chromene-2-Carboxylic Acid
CAS No.	105799-81-3
Molecular Formula	C₁₂H₇FO₃S
Molecular Weight	250.25 g/mol
Synonyms	8-Fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid; 8-Fluoro-2-carboxy-4H-thieno[3,2-c]chromene; 8-Fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid; 105799-81-3; 8-Fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid; Thienochromene-2-carboxylic acid, 8-fluoro-4H-; 8-Fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid (ACI)
EINECS	Contact for details

Quality Control

Every batch of 8-Fluoro-4H-Thieno[3,2-C]Chromene-2-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.