Description

Cyclopropanecarboxylic Acid, 2-Fluoro-2-Methoxy-, Methyl Ester, cis- (9Ci) is a high-purity, fluorinated cyclopropane derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters for its unique stereochemistry and functional groups, enabling the construction of complex molecular architectures with precise spatial orientation. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its cis-configuration and methoxy-fluoro substitution pattern are key design elements.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorinated cyclopropane core can enhance biological activity and environmental stability.
• Chemical Research & Development: Serves as a versatile scaffold in methodological studies for novel cyclopropanation reactions and fluorine chemistry.
• Ligand & Catalyst Preparation: Potential precursor for synthesizing specialized chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Can be investigated for incorporation into specialty polymers or liquid crystals, leveraging its rigid cyclopropane ring and fluorine atom.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Fluoro-2-Methoxy-, Methyl Ester, cis- (9Ci)
CAS No.	105783-72-0
Molecular Formula	C7H11FO3
Molecular Weight	162.16 g/mol
Synonyms	Methyl cis-2-fluoro-2-methoxycyclopropanecarboxylate; cis-Methyl 2-fluoro-2-methoxycyclopropanecarboxylate; 2-Fluoro-2-methoxycyclopropanecarboxylic acid methyl ester, cis-; (1R,2S)- or (1S,2R)-Methyl 2-fluoro-2-methoxycyclopropanecarboxylate; Fluoromethoxycyclopropane carboxylate methyl ester; Cyclopropanecarboxylic acid, 2-fluoro-2-methoxy-, methyl ester, (1R,2S)-rel-; CAS 105783-72-0
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Fluoro-2-Methoxy-, Methyl Ester, cis- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (cis-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.