Description

Fmoc-D-Pipecolic Acid CAS NO 105751-19-7 is a high-purity, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the creation of complex peptides and peptidomimetics with enhanced metabolic stability and bioavailability. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and CROs/CDMOs focused on developing novel therapeutic agents, diagnostic tools, and biochemical research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid for the automated synthesis of therapeutic peptides.
• Pharmaceutical Research: Used in the development of peptide-based drugs targeting GPCRs, enzymes, and other biological pathways.
• Peptidomimetic Design: Incorporation of the D-pipecolic acid scaffold helps create analogs with improved stability against proteolytic degradation.
• Combinatorial Chemistry: A valuable reagent for generating diverse peptide libraries for high-throughput screening.
• Bioconjugation: Can be used to introduce specific functional handles or linkers into peptides for labeling or conjugation purposes.
• Academic & Biochemical Research: Employed in studies of protein-protein interactions, enzyme inhibitors, and structural biology.

Basic Information

Product Name	Fmoc-D-Pipecolic Acid
CAS No.	105751-19-7
Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-D-Pip-OH; (R)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-pipecolic acid; D-Pipecolic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-D-Homopro-OH; N-Fmoc-D-pipecolic acid; Fmoc-D-Pipe; Fmoc-D-Pipecolate
EINECS	Contact for details

Quality Control

Our Fmoc-D-Pipecolic Acid is manufactured under strict quality systems to ensure consistency and reliability for sensitive synthetic applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and chiral integrity, and is supported by a comprehensive Certificate of Analysis (COA). We adhere to cGMP principles where applicable to support our customers in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.