Description

H-α-Me-Leu-Oh is a non-proteinogenic amino acid derivative, specifically a methylated leucine analog, with the CAS registry number 105743-53-1. This specialized building block is critical for advanced peptide synthesis and medicinal chemistry research, enabling the creation of novel compounds with modified biological activity and stability. It is primarily utilized by pharmaceutical R&D teams, peptide manufacturers, and academic research institutions focused on developing new therapeutic agents and studying protein structure-function relationships.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified leucine residues, altering peptide properties like hydrophobicity and metabolic stability.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of α-methylation on peptide bioactivity and receptor binding.
• Bioconjugation: Serves as a linker or modified amino acid in the development of peptide-drug conjugates and other bioconjugates.
• Biochemical Tool Development: Utilized to create custom peptides for use as probes, inhibitors, or standards in biochemical assays.
• Academic & Industrial R&D: Fundamental research material in universities and corporate labs for exploring new synthetic methodologies and bioactive compounds.

Basic Information

Product Name	H-α-Me-Leu-Oh
CAS No.	105743-53-1
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	(S)-2-Amino-2-methyl-4-methylpentanoic acid; (S)-2-Amino-2-methyl-4-methylvaleric acid; L-α-Methylleucine; (S)-α-Methylleucine; H-α-Me-Leu-OH; α-Methyl-L-leucine; 2-Amino-2-methyl-4-methylpentanoic acid, L-; 2-Methyl-2-aminopentanoic acid, 4-methyl-
EINECS	Contact for details

Quality Control

Our H-α-Me-Leu-Oh is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be aligned with client requirements for advanced synthetic work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.