Description

Ammodytoxin B is a highly specific phospholipase A2 (PLA2) enzyme isolated from snake venom, primarily from the species *Vipera ammodytes*. This compound is of significant value in biochemical and pharmacological research due to its potent and selective mechanism of action. It serves as a critical tool for scientists studying neurotoxicity, myotoxicity, and the fundamental role of PLA2 in inflammatory pathways and cell signaling. Key target users include research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on neuroscience, toxicology, and anti-venom development.

Application

• Biochemical Research: Used as a standard or probe to study the structure, function, and inhibition mechanisms of phospholipase A2 enzymes.
• Neuroscience Studies: Employed in models to investigate presynaptic neurotoxicity and its effects on neurotransmitter release.
• Toxicology & Anti-venom Development: Acts as a key antigen and reference toxin for the production and efficacy testing of antivenoms.
• Pharmacological Screening: Utilized in high-throughput assays to identify and characterize novel PLA2 inhibitors with therapeutic potential for inflammatory diseases.
• Cell Biology: Applied to study membrane dynamics, lipid metabolism, and apoptosis triggered by specific enzymatic activity.
• Diagnostic Reagent Manufacturing: Serves as a calibrated component in diagnostic kits for detecting specific venom antibodies or PLA2 activity in clinical samples.

Basic Information

Product Name	Ammodytoxin B
CAS No.	105732-90-9
Molecular Formula	C132H202N38O41S8 (Approximate, for main isoform)
Molecular Weight	~13.8 kDa (Approximate)
Synonyms	Vipera ammodytes ammodytes phospholipase A2 homolog; Ammodytoxin B; AtxB; PLA2 homolog; Snake venom group IIA phospholipase A2; Presynaptic neurotoxin; Vipera ammodytes ammodytes toxin; Basic phospholipase A2 Vaa-2; EC 3.1.1.4 (Phospholipase A2 activity)
EINECS	Contact for details

Quality Control

Our Ammodytoxin B is produced and purified under stringent conditions to ensure high biological activity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including assessment of purity, specific enzymatic activity, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as purity (by HPLC), protein concentration, and specific phospholipase A2 activity. We adhere to rigorous quality management practices suitable for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted to avoid repeated freeze-thaw cycles and stored at -70°C or lower. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under anhydrous conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Protein Content (UV)	≥ 90%
Specific Activity	≥ 150 units/mg protein
Endotoxin Level (LAL)	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers (e.g., PBS, Tris)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.