Description

Exametazime is a bifunctional chelating agent primarily used for the radiolabeling of antibodies and other biomolecules for diagnostic imaging. Its core value lies in enabling the stable conjugation of the radioisotope Technetium-99m (99mTc) to targeting vectors, forming a critical component in the development of radiopharmaceuticals. This product is essential for research institutions, pharmaceutical developers, and diagnostic imaging centers focused on oncology, cardiology, and neurology.

Application

• Primary component in the preparation of Kit for Technetium Tc 99m Exametazime, a brain perfusion imaging agent.
• Critical reagent for the radiolabeling of monoclonal antibodies and peptides with 99mTc for targeted cancer imaging (immuno-SPECT).
• Used in research and development of novel radiopharmaceuticals for diagnostic applications in cardiology and inflammation.
• Chelating agent in the synthesis of radiometal complexes for preclinical and clinical molecular imaging studies.
• Key intermediate in the production of single-photon emission computed tomography (SPECT) tracers.

Basic Information

Product Name	Exametazime
CAS No.	105613-48-7
Molecular Formula	C20H32N6O4
Molecular Weight	420.51 g/mol
Synonyms	HMPAO; d,l-HMPAO; Hexamethylpropyleneamine oxime; Ceretec™ (Kit component); Exametazime (USAN); NSC-D-699596; (3RS,8RS,10RS)-3,6,10,13,13-Pentamethyl-3,10-bis(2-methylpropyl)-1,4,7,11-tetraazacyclotridecane-2,5,8,11-tetraone
EINECS	Contact for details

Quality Control

Our Exametazime is manufactured under strict quality systems suitable for pharmaceutical research and development. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.