Description

(S)-(-)-4-Methylmandelonitrile is a high-purity chiral nitrile building block of significant importance in asymmetric synthesis. This compound serves as a versatile intermediate for the construction of complex pharmaceutical molecules and fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate stereochemical complexity into their target compounds.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system.
• Asymmetric Synthesis: Used as a starting material or resolving agent in stereoselective reactions to create enantiomerically pure compounds.
• Agrochemical Research: Employed in the development of novel, optically active herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Serves as a building block for chiral ligands and organocatalysts used in transition metal catalysis and other catalytic processes.
• Fine Chemical Production: Integral to the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and the exploration of new synthetic pathways.

Basic Information

Product Name	(S)-(-)-4-Methylmandelonitrile
CAS No.	105452-15-1
Molecular Formula	C9H9NO
Molecular Weight	147.17 g/mol
Synonyms	(S)-(-)-4-Methylmandelonitrile; (S)-4-Methylmandelonitrile; (S)-α-Hydroxy-4-methylbenzeneacetonitrile; (S)-2-Hydroxy-2-(4-methylphenyl)acetonitrile; (S)-(-)-4-Methylbenzaldehyde cyanohydrin; (S)-p-Methylmandelonitrile; (S)-4-Methylbenzyl cyanohydrin; (S)-Oxygen-cyanomethyl-4-methylbenzene
EINECS	Contact for details

Quality Control

Our (S)-(-)-4-Methylmandelonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.