Description

6-Fluoro-3-Hydroxyisobenzofuran-1(3H)-One is a specialized fluorinated isobenzofuranone derivative, serving as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring both a fluorine atom and a hydroxyl group on the fused ring system, makes it a valuable precursor for developing novel active pharmaceutical ingredients (APIs) and fine chemicals. This compound is primarily sought by research and development teams in the pharmaceutical, agrochemical, and material science industries for creating compounds with enhanced biological activity and specific physical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in developing novel herbicides and pesticides where the fluorine atom can improve metabolic stability and bioavailability.
• Material Science Precursor: Acts as a monomer or functionalizing agent for creating specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in the design of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Studies: Serves as a model compound in academic and industrial research exploring the effects of fluorine substitution on reactivity and conformation.
• Fine Chemical Synthesis: Utilized for the preparation of complex, high-value fluorinated fragrance and flavor intermediates.

Basic Information

Product Name	6-Fluoro-3-Hydroxyisobenzofuran-1(3H)-One
CAS No.	105398-58-1
Molecular Formula	C8H5FO3
Molecular Weight	168.12 g/mol
Synonyms	6-Fluoro-3-hydroxy-1(3H)-isobenzofuranone; 3-Hydroxy-6-fluorophthalide; 6-Fluorophthalide-3-ol; 6-Fluoro-3-hydroxyphthalide; 6-Fluoro-3-hydroxylactone; 105398-58-1; 6-Fluoro-3-hydroxy-1,3-dihydroisobenzofuran-1-one
EINECS	Contact for details

Quality Control

Our 6-Fluoro-3-Hydroxyisobenzofuran-1(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.