Description

1H-Indazol-5-Yl Trifluoromethyl Ether is a high-value fluorinated heterocyclic building block, essential for advanced pharmaceutical and agrochemical research. Its core value lies in the trifluoromethoxy group, which significantly enhances the metabolic stability, lipophilicity, and bioavailability of target molecules. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides, leveraging the trifluoromethoxy group's properties.
• Material Science: Serves as a precursor for specialty polymers and advanced organic electronic materials.
• Chemical Biology: Employed as a probe or labeling agent in biochemical assays due to its unique structural motif.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1H-Indazol-5-Yl Trifluoromethyl Ether
CAS No.	105391-76-2
Molecular Formula	C9H5F3N2O
Molecular Weight	214.14 g/mol
Synonyms	5-(Trifluoromethoxy)-1H-indazole; 1H-Indazole, 5-(trifluoromethoxy)-; 5-(Trifluoromethoxy)indazole; 5-Trifluoromethoxy-1H-indazole; 105391-76-2; 5-Trifluoromethoxyindazole; 1H-Indazol-5-ol, trifluoromethyl ether
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. We provide material with typical purity grades suitable for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Purity (HPLC)	≥95% (Research Grade)
Purity (HPLC)	≥98% (Premium Grade)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.