Description

n-Desethyl Milnacipran is a key pharmaceutical intermediate and metabolite of the antidepressant Milnacipran. This compound is of significant importance for analytical and research purposes, particularly in the fields of pharmacology and drug metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards for method development, bioanalytical testing, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of Milnacipran and its related substances.
• Metabolite Studies: Critical for in-vitro and in-vivo pharmacokinetic research to understand the metabolic pathway and clearance of Milnacipran.
• Impurity Profiling: Serves as a specified impurity (degradant or metabolite) in the quality control of Milnacipran Active Pharmaceutical Ingredient (API) and finished dosage forms.
• Bioanalytical Method Development: Employed as a standard for developing and validating HPLC, LC-MS, or GC-MS methods in biological matrices.
• Pharmacology Research: Used in studies to investigate the structure-activity relationship (SAR) and the pharmacological role of Milnacipran metabolites.
• Regulatory Compliance: Essential for preparing documentation and analytical data for regulatory submissions (e.g., FDA, EMA) related to Milnacipran-based products.

Basic Information

Product Name	n-Desethyl Milnacipran
CAS No.	105310-07-4
Molecular Formula	C13H18N2O
Molecular Weight	218.30 g/mol
Synonyms	1-(1-Phenylcyclopropylmethylamino)-2-aminopropane; F 2207 Desethyl; Desethyl Milnacipran; Milnacipran Desethyl Metabolite; Milnacipran Impurity; (1R*,2S*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide (related isomer); F 2696 (developmental code)
EINECS	Contact for details

Quality Control

Our n-Desethyl Milnacipran is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of specific impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.