Description

(S)-3-Methoxymandelonitrile is a chiral, non-racemic cyanohydrin derivative, a key intermediate in the synthesis of enantiomerically pure compounds. Its value lies in its utility as a versatile building block for constructing complex molecules with defined stereochemistry, crucial for achieving desired biological activity. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on active pharmaceutical ingredients (APIs), chiral ligands, and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiopure drugs, including β-blockers, antidepressants, and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry is required for efficacy and environmental safety.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and auxiliaries used in asymmetric synthesis to induce high enantioselectivity.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require precise stereochemical control.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and for exploring new reaction pathways in process chemistry.

Basic Information

Product Name	(S)-3-Methoxymandelonitrile
CAS No.	105307-09-3
Molecular Formula	C9H9NO2
Molecular Weight	163.17 g/mol
Synonyms	(S)-(-)-3-Methoxymandelonitrile; (S)-α-Hydroxy-3-methoxybenzeneacetonitrile; (S)-2-Hydroxy-2-(3-methoxyphenyl)acetonitrile; (S)-3-Methoxybenzaldehyde cyanohydrin; (S)-3-Methoxyphenylglycolonitrile; (S)-Mandelonitrile, 3-methoxy-; (S)-3-Methoxy-α-hydroxybenzeneacetonitrile
EINECS	Contact for details

Quality Control

Our (S)-3-Methoxymandelonitrile is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. We employ advanced analytical techniques, including chiral HPLC, to verify enantiomeric excess (ee) and overall purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.