Description

3,5-Difluorophenylacetic Acid is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its difluorophenyl moiety imparts desirable metabolic stability and bioavailability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Building block for developing modern herbicides and fungicides with enhanced efficacy and environmental profiles.
• Liquid Crystal Materials: Used in the production of fluorinated components for electronic display technologies.
• Organic Light-Emitting Diodes (OLEDs): Serves as a starting material for electron-transport or host materials in OLED devices.
• Peptide Mimetics & Bio-conjugates: The acetic acid functionality allows for coupling to create fluorinated peptide analogs or labeling agents.
• Material Science Research: Employed in creating novel polymers and advanced organic frameworks with specific fluorinated properties.

Basic Information

Product Name	3,5-Difluorophenylacetic Acid
CAS No.	105184-38-1
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	(3,5-Difluorophenyl)acetic Acid; 2-(3,5-Difluorophenyl)acetic Acid; 3,5-Difluorobenzeneacetic Acid; α-(3,5-Difluorophenyl)acetic Acid; NSC 405124; 105184-38-1; 3,5-Difluorophenyl Acetate (common misnomer)
EINECS	Contact for details

Quality Control

Our 3,5-Difluorophenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), related substances, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.