Description

3-[n-Tris(Hydroxymethyl)Methylamino]-2-Hydroxypropanesulfonic Acid Sodium Salt is a high-purity, zwitterionic biological buffer salt, essential for maintaining precise pH stability in sensitive biochemical and diagnostic systems. Its primary value lies in its excellent buffering capacity in the physiological pH range, combined with minimal interference with biological processes and metal ion chelation. This makes it a critical reagent for researchers and manufacturers in molecular biology, cell culture, diagnostic assay development, and pharmaceutical formulation.

Application

• Biochemical & Molecular Biology Research: As a primary or secondary buffer component in enzyme assays, protein purification, electrophoresis (e.g., SDS-PAGE), and PCR.
• Cell Culture Media: For pH stabilization in mammalian and bacterial cell culture systems, providing a stable ionic environment.
• Diagnostic Reagents: Formulation of buffers for clinical chemistry analyzers, immunoassays (ELISA), and point-of-care testing strips.
• Pharmaceutical Formulation: Used as an excipient buffer in parenteral solutions, ophthalmics, and other injectable products requiring precise pH control.
• Chromatography: Mobile phase modifier in ion-exchange and affinity chromatography for biomolecule separation.
• Cosmetic & Personal Care: pH adjustment and stabilization in high-value skincare and haircare formulations.

Basic Information

Product Name	3-[n-Tris(Hydroxymethyl)Methylamino]-2-Hydroxypropanesulfonic Acid Sodium Salt
CAS No.	105140-25-8
Molecular Formula	C7H16NNaO7S
Molecular Weight	281.26 g/mol
Synonyms	TAPSO Sodium Salt; 3-[N-Tris(hydroxymethyl)methylamino]-2-hydroxypropanesulfonic Acid Sodium Salt; TAPSO-Na; N-Tris(Hydroxymethyl)Methyl-3-Amino-2-Hydroxypropanesulfonic Acid Sodium Salt; (2-Hydroxy-3-[tris(hydroxymethyl)methylamino]-1-propanesulfonic Acid Sodium Salt); Biological Buffer TAPSO Sodium Salt; Good's Buffer TAPSO Sodium Salt
EINECS	Contact for details

Quality Control

Our 3-[n-Tris(Hydroxymethyl)Methylamino]-2-Hydroxypropanesulfonic Acid Sodium Salt is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity suitable for research and industrial applications. Each lot is supplied with a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can support compliance requirements for cGMP, ISO, and REACH as needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
pH (1% Solution)	7.0 - 7.5
Loss on Drying	≤ 2.0%
Heavy Metals (as Pb)	≤ 20 ppm
Endotoxin (LAL)	< 0.25 EU/mg (for applicable grades)
Filterability (0.2 µm)	Clear, colorless solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.