Description

Ciprofloxacin β-D-Glucuronide is a crucial conjugated metabolite of the widely used fluoroquinolone antibiotic, ciprofloxacin. This compound is essential for analytical and research purposes, serving as a primary reference standard for the accurate detection and quantification of ciprofloxacin and its metabolites in biological matrices. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic manufacturers engaged in drug metabolism and pharmacokinetic (DMPK) studies, bioanalytical method development, and clinical toxicology.

Application

• Bioanalytical Reference Standard: Primary use as a certified reference material for the quantification of ciprofloxacin metabolites in plasma, serum, and urine via LC-MS/MS or HPLC.
• Pharmacokinetic & DMPK Studies: Critical for investigating the metabolic pathways, clearance rates, and bioavailability of ciprofloxacin in preclinical and clinical research.
• Clinical Toxicology & Therapeutic Drug Monitoring (TDM): Enables precise measurement of drug and metabolite levels to ensure therapeutic efficacy and patient safety.
• Veterinary Drug Residue Analysis: Used in testing for ciprofloxacin residues in food-producing animals to ensure compliance with maximum residue limits (MRLs).
• Enzyme Activity Assays: Serves as a specific substrate for studying the activity of UDP-glucuronosyltransferase (UGT) enzymes in vitro.
• Method Development & Validation: Essential for developing, calibrating, and validating robust analytical methods in regulatory-compliant laboratories (FDA, EMA).

Basic Information

Item	Detail
Product Name	Ciprofloxacin β-D-Glucuronide
CAS No.	105029-31-0
Molecular Formula	C27H31FN4O9
Molecular Weight	574.56 g/mol
Synonyms	Ciprofloxacin β-D-Glucuronide; Ciprofloxacin Glucuronide; 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid β-D-glucopyranuronate; Ciprofloxacin 1-β-Glucuronide; Ciprofloxacin Glucuronide Conjugate; Bay q 3939 Glucuronide; (1S,2S,3R,4S)-4-({1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carbonyl}oxy)-2,3,5-trihydroxycyclohexane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our Ciprofloxacin β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and determination of residual solvents and water content. We provide comprehensive Certificates of Analysis (COA) with detailed chromatograms and spectroscopic data to support your regulatory filings and ensure traceability and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.